Interpretes Principales: Omar Epps (Dr. Eric Foreman), Jennifer Morrison (Dr. Allison Cameron), Lisa Edelstein (Dr. Lisa Cuddy), Hugh Laurie (Dr. Gregory House), Jesse Spencer (Dr. Robert Chase), Robert Sean Leonard (Dr. James Wilson).
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Otros Artistas: Cole Evan Weiss (Chico), Shyann McClure (Chica), Teddy Vincent (Señora Zebalusky), Michael Medico (Doctor), Meredith Eaton-Gilden (Maddy), Kacie Borrowman (Abigail), David Morse (Detective Michael Tritter), Bobbin Bergstrom (Enfermera), Marco Pelaez (Farmaceutico).
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