Interpretes Principales: Lisa Edelstein (Dr. Lisa Cuddy), Omar Epps (Dr. Eric Foreman), Hugh Laurie (Dr. Gregory House), Robert Sean Leonard (Dr. James Wilson), Jesse Spencer (Dr. Robert Chase), Jennifer Morrison (Dr. Allison Cameron.).
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Otros Artistas: Paul Sklar (Policía), Smith Cho (Julia), Leslie Hope (Victoria Madsen), Ogy Durham (Chris), Charles C. Stevenson Jr. (Walter), Troy Robinson (Policía), Patty Onagan (Novia), Tomiko Martinez (Chica alta), Brandon Bracato (Phil), Bonnie Perlman (Madre), Farrah Skyler Greye (Enfermera), Suzanne Ford (Mrs. Whitney), Leslie Karpman (Jodi.).
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