Interpretes Habituales

- Matthew Fox
- Dominic Monaghan
- Daniel Dae Kim
- Terry OQuinn
- Harold Perrineau Jr.
- Emilie de Ravin
- Naveen Andrews
- Ian Somerhalder
- Jorge Garcia
- Malcolm David Kelley
- Maggie Grace
- Josh Holloway
- Evangeline Lilly
- Yunjin Kim
- Adewale Akinnuoye-Agbaje
- Michael Emerson
- Michelle Rodriguez
- Sun Kwon
- Jack Shepard
- Libby
- Cynthia Watros
- Recurring Role: L. Scott Caldwell
- Sam Anderson
- .
- Season 2-
- Rodrigo Santoro
- Henry Ian Cusick
- Elizabeth Mitchell
- Kiele Sanchez
- Michael Bowen
- Season 3 recurring previously

Otros Interpretes que aparecen en la serie

- Fredric Lehne
- L. Scott Caldwell
- Kimberley Joseph
- Greg Grunberg
- John Dixon
- Michelle Arthur
- George Alan
- Nick Tate
- Meilinda Soerjoko
- John Simon Jones
- Billy Ray Gallion
- Stephen J. Rafferty
- John Terry
- Andy Trask
- Veronica Hamel

Directores

- J.J. Abrams
- Jack Bender
- Kevin Hooks
- Michael Zinberg
- Tucker Gates
- Marita Grabiak
- Stephen Williams
- Rod Holcomb
- Greg Yaitanes
- Dan Tallias
- Robert Mandel
- David Grossman
- Alan Taylor
- Adam Davidson
- Eric Laneuville