Interpretes Principales: Mary-Louise Parker (Nancy Botwin), Elizabeth Perkins (Celia Hodes), Romany Malco (Conrad Shepard), Justin Kirk (Andy Botwin), Kevin Nealon (Doug Wilson), Alexander Gould (Shane Botwin), Hunter Parrish (Silas Botwin), Renée Victor (Lupita), Indigo (Vaneeta), Tonye Patano (Heylia James).
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Otros Artistas: Eden Sher (Gretchen), Meital Dohan (Yael Hoffman), Maulik Pancholy (Sanjay), Martin Donovan (Peter Scottson), Dave Thomas (Dr. Bertner), Daryl Sabara (Tim Scottson), Andy Milder (Dean Hodes).
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